味道是遵循社会趋势和行为的风味行业的焦点。新调味剂和分子的研究和开发在该领域至关重要。另一方面，自然风味的发展在现代社会中起着至关重要的作用。鉴于此，目前的工作提出了一个基于科学机器学习的新颖框架，以在风味工程和行业中解决新的问题。因此，这项工作带来了一种创新的方法来设计新的自然风味分子。评估了有关合成可及性，原子数以及与天然或伪天然产物的相似性的分子。

在许多实际应用程序中，强化学习（RL）代理可能必须解决多个任务，每个任务通常都是通过奖励功能建模的。如果奖励功能是线性表达的，并且代理商以前已经学会了一组针对不同任务的策略，则可以利用后继功能（SFS）来组合此类策略并确定有关新问题的合理解决方案。但是，确定的解决方案不能保证是最佳的。我们介绍了一种解决此限制的新颖算法。它允许RL代理结合现有政策并直接确定任意新问题的最佳政策，而无需与环境进行任何进一步的互动。我们首先（在轻度假设下）表明，SFS解决的转移学习问题等同于学习在RL中优化多个目标的学习问题。然后，我们引入了基于SF的乐观线性支持算法的扩展，以学习一组SFS构成凸面覆盖范围集的策略。我们证明，该集合中的策略可以通过广义策略改进组合，以构建任何可表达的新任务的最佳行为，而无需任何其他培训样本。我们从经验上表明，在价值函数近似下，我们的方法在离散和连续域中优于最先进的竞争算法。

推断基于实验观察的随机模型的参数是科学方法的核心。特别具有挑战性的设置是当模型强烈不确定时，即当不同的参数集产生相同的观察时。这在许多实际情况下出现，例如在推断无线电源的距离和功率时（是源关闭和弱或远远强，且强大且强大？）或估计电生理实验的放大器增益和底层脑活动。在这项工作中，我们通过利用由辅助观察集共享全局参数传达的附加信息来阐明这种不确定性的新方法。我们的方法基于对贝叶斯分层模型的标准化流程扩展了基于仿真的推断（SBI）的最新进展。我们通过模拟和实际EEG数据将其应用于可用于分析解决方案的激励示例，以便将其验证我们的提案，然后将其从计算神经科学逆变众所周知的非线性模型。

There are multiple scales of abstraction from which we can describe the same image, depending on whether we are focusing on fine-grained details or a more global attribute of the image. In brain mapping, learning to automatically parse images to build representations of both small-scale features (e.g., the presence of cells or blood vessels) and global properties of an image (e.g., which brain region the image comes from) is a crucial and open challenge. However, most existing datasets and benchmarks for neuroanatomy consider only a single downstream task at a time. To bridge this gap, we introduce a new dataset, annotations, and multiple downstream tasks that provide diverse ways to readout information about brain structure and architecture from the same image. Our multi-task neuroimaging benchmark (MTNeuro) is built on volumetric, micrometer-resolution X-ray microtomography images spanning a large thalamocortical section of mouse brain, encompassing multiple cortical and subcortical regions. We generated a number of different prediction challenges and evaluated several supervised and self-supervised models for brain-region prediction and pixel-level semantic segmentation of microstructures. Our experiments not only highlight the rich heterogeneity of this dataset, but also provide insights into how self-supervised approaches can be used to learn representations that capture multiple attributes of a single image and perform well on a variety of downstream tasks. Datasets, code, and pre-trained baseline models are provided at: https://mtneuro.github.io/ .

The availability of frequent and cost-free satellite images is in growing demand in the research world. Such satellite constellations as Landsat 8 and Sentinel-2 provide a massive amount of valuable data daily. However, the discrepancy in the sensors' characteristics of these satellites makes it senseless to use a segmentation model trained on either dataset and applied to another, which is why domain adaptation techniques have recently become an active research area in remote sensing. In this paper, an experiment of domain adaptation through style-transferring is conducted using the HRSemI2I model to narrow the sensor discrepancy between Landsat 8 and Sentinel-2. This paper's main contribution is analyzing the expediency of that approach by comparing the results of segmentation using domain-adapted images with those without adaptation. The HRSemI2I model, adjusted to work with 6-band imagery, shows significant intersection-over-union performance improvement for both mean and per class metrics. A second contribution is providing different schemes of generalization between two label schemes - NALCMS 2015 and CORINE. The first scheme is standardization through higher-level land cover classes, and the second is through harmonization validation in the field.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Plastic shopping bags that get carried away from the side of roads and tangled on cotton plants can end up at cotton gins if not removed before the harvest. Such bags may not only cause problem in the ginning process but might also get embodied in cotton fibers reducing its quality and marketable value. Therefore, it is required to detect, locate, and remove the bags before cotton is harvested. Manually detecting and locating these bags in cotton fields is labor intensive, time-consuming and a costly process. To solve these challenges, we present application of four variants of YOLOv5 (YOLOv5s, YOLOv5m, YOLOv5l and YOLOv5x) for detecting plastic shopping bags using Unmanned Aircraft Systems (UAS)-acquired RGB (Red, Green, and Blue) images. We also show fixed effect model tests of color of plastic bags as well as YOLOv5-variant on average precision (AP), mean average precision (mAP@50) and accuracy. In addition, we also demonstrate the effect of height of plastic bags on the detection accuracy. It was found that color of bags had significant effect (p < 0.001) on accuracy across all the four variants while it did not show any significant effect on the AP with YOLOv5m (p = 0.10) and YOLOv5x (p = 0.35) at 95% confidence level. Similarly, YOLOv5-variant did not show any significant effect on the AP (p = 0.11) and accuracy (p = 0.73) of white bags, but it had significant effects on the AP (p = 0.03) and accuracy (p = 0.02) of brown bags including on the mAP@50 (p = 0.01) and inference speed (p < 0.0001). Additionally, height of plastic bags had significant effect (p < 0.0001) on overall detection accuracy. The findings reported in this paper can be useful in speeding up removal of plastic bags from cotton fields before harvest and thereby reducing the amount of contaminants that end up at cotton gins.

In this paper, a complete framework for Autonomous Self Driving is implemented. LIDAR, Camera and IMU sensors are used together. The entire data communication is managed using Robot Operating System which provides a robust platform for implementation of Robotics Projects. Jetson Nano is used to provide powerful on-board processing capabilities. Sensor fusion is performed on the data received from the different sensors to improve the accuracy of the decision making and inferences that we derive from the data. This data is then used to create a localized map of the environment. In this step, the position of the vehicle is obtained with respect to the Mapping done using the sensor data.The different SLAM techniques used for this purpose are Hector Mapping and GMapping which are widely used mapping techniques in ROS. Apart from SLAM that primarily uses LIDAR data, Visual Odometry is implemented using a Monocular Camera. The sensor fused data is then used by Adaptive Monte Carlo Localization for car localization. Using the localized map developed, Path Planning techniques like "TEB planner" and "Dynamic Window Approach" are implemented for autonomous navigation of the vehicle. The last step in the Project is the implantation of Control which is the final decision making block in the pipeline that gives speed and steering data for the navigation that is compatible with Ackermann Kinematics. The implementation of such a control block under a ROS framework using the three sensors, viz, LIDAR, Camera and IMU is a novel approach that is undertaken in this project.

Importance: Social determinants of health (SDOH) are known to be associated with increased risk of suicidal behaviors, but few studies utilized SDOH from unstructured electronic health record (EHR) notes. Objective: To investigate associations between suicide and recent SDOH, identified using structured and unstructured data. Design: Nested case-control study. Setting: EHR data from the US Veterans Health Administration (VHA). Participants: 6,122,785 Veterans who received care in the US VHA between October 1, 2010, and September 30, 2015. Exposures: Occurrence of SDOH over a maximum span of two years compared with no occurrence of SDOH. Main Outcomes and Measures: Cases of suicide deaths were matched with 4 controls on birth year, cohort entry date, sex, and duration of follow-up. We developed an NLP system to extract SDOH from unstructured notes. Structured data, NLP on unstructured data, and combining them yielded seven, eight and nine SDOH respectively. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. Results: In our cohort, 8,821 Veterans committed suicide during 23,725,382 person-years of follow-up (incidence rate 37.18 /100,000 person-years). Our cohort was mostly male (92.23%) and white (76.99%). Across the six common SDOH as covariates, NLP-extracted SDOH, on average, covered 84.38% of all SDOH occurrences. All SDOH, measured by structured data and NLP, were significantly associated with increased risk of suicide. The SDOH with the largest effects was legal problems (aOR=2.67, 95% CI=2.46-2.89), followed by violence (aOR=2.26, 95% CI=2.11-2.43). NLP-extracted and structured SDOH were also associated with suicide. Conclusions and Relevance: NLP-extracted SDOH were always significantly associated with increased risk of suicide among Veterans, suggesting the potential of NLP in public health studies.

Self-similarity is valuable to the exploration of non-local textures in single image super-resolution (SISR). Researchers usually assume that the importance of non-local textures is positively related to their similarity scores. In this paper, we surprisingly found that when repairing severely damaged query textures, some non-local textures with low-similarity which are closer to the target can provide more accurate and richer details than the high-similarity ones. In these cases, low-similarity does not mean inferior but is usually caused by different scales or orientations. Utilizing this finding, we proposed a Global Learnable Attention (GLA) to adaptively modify similarity scores of non-local textures during training instead of only using a fixed similarity scoring function such as the dot product. The proposed GLA can explore non-local textures with low-similarity but more accurate details to repair severely damaged textures. Furthermore, we propose to adopt Super-Bit Locality-Sensitive Hashing (SB-LSH) as a preprocessing method for our GLA. With the SB-LSH, the computational complexity of our GLA is reduced from quadratic to asymptotic linear with respect to the image size. In addition, the proposed GLA can be integrated into existing deep SISR models as an efficient general building block. Based on the GLA, we constructed a Deep Learnable Similarity Network (DLSN), which achieves state-of-the-art performance for SISR tasks of different degradation types (e.g. blur and noise). Our code and a pre-trained DLSN have been uploaded to GitHub{\dag} for validation.